... , is also present in the same source.Mechanism of action:Camptothecin affects the activity of the enzyme topoisomerase I, whose normal ... action is to cleave, unwind, and religate DNA. When camptothecin binds to topoisomerase I, it will be able to cleave ... but not to religate DNA. Thereby, camptothecin causes single strand breaks in DNADescription: Brown crystalline powder; easy ...