The material refined by mcroporous resin adsorption is highly enriched the active ingredients,fewer impurities.
Macroporous resin column
System components and their characteristics
Automation control system based on the advanced DCS distributed control strategy for the preparation of the workstation, to achieve the pumps, valves and various online detector control and data acquisition, to facilitate the completion of more columns in series, parallel operation, to ensure process stability and accuracy.
System components and their characteristics
(1) Automatic Control Systems
System implementation of the pumps, valves and various online detector (flow transmitter, pressure transmitter) control and data acquisition, to facilitate the completion of four-post series, parallel operation, to ensure process stability and accuracy.
(2) Resin column structure
The resin column structure is well-designed, reasonably high aspect ratio, import and export of precision fluid distribution device, equipped with automatic loading system, compressed air and air interface, to ensure the effect of macroporous resin column filling and packing regeneration, provides for the efficient separation protection.
Herb medicine proprietary online testing system (optional)
Including flow, pressure, temperature, PH value (optional), conductivity (optional) and other conventional process parameters and the use of UV detection (optional), near-infrared spectroscopy (optional) ingredients for traditional Chinese medicine effective real-time detection . In the separation process use introduction of computer technology, automatic control, production program control, testing automation, pipelines, and improve equipment reliability and repeatability
Macroporous resin column control unit
Control resume
1. Runoff than the control flow control
2 washing volume control
3 washing end monitoring experience value (or optional infrared control)
4. Eluted with ethanol (or other solvent) control
5. Eluting end monitoring experience value (or near-infrared control optional)
6 filler acid regeneration control
Adsorption control points
Adsorption chromatography, ion exchange process is a process, in which we control the main control object to control the liquid flow rate of adsorption, the control process include: adsorption (including counter-current washing column, washing, adsorption, desorption, regeneration ) and process control, the main control object and parameters:
1. Countercurrent wash column: with a broken washing to remove small particles and filler.
2.adsorption: adsorption according to 14BV / H adsorption liquid active ingredient, usually PH = 5-8, temperature <50 °C degrees best.
3. water elution: water to 2-3BV / H will be adsorbed on the packing of the impurities washed out.
4. Desorption: ethanol and other solvents to 0.5-3BV / H dissolution of the active ingredient.
5. Regeneration: the use of renewable liquid (acid or alkaline) 0.5-3BV / H; restore the adsorption capacity of filler.
6. water cleaning; regeneration after filling with water.
7. BV explanation: usually installed in the cylinder-shaped packing chromatography columns, the solution continuously through, chromatography column packing volume as bed load volume (bed volume), abbreviated as BV. Industrial use of bed volume chromatography column is usually 1-10M3, also has a smaller or larger. This is the basic unit of chromatography columns, it works when the quantity of material to BV as a unit. For example, solution flow rate through the chromatography column for the 2-4BV / H, the volume per hour through the solution for the chromatography bed volume of 2-4 times. Packing capacity fairly frequently in BV for the unit. In the traditional adsorption, washing, desorption, regeneration control process stage, the object is to control the feed rate of the adsorption column, the control valve and flow meter installed in the import of liquid in the adsorption column of the discharge port to install a switch valve This is controlled from the surface on the adsorption rate within the required range,
Adsorption control
Liquid adsorption control of control is the most critical flow rate of liquid adsorption control, and the adsorption control on the liquid chromatography column at the feed valve to open when the liquid seasoning of the required level The height control valve to open the material, the normal flow control adsorption, adsorption control in the normal time up and down through the liquid chromatography column chromatography column of liquid level control switch, so that adsorption is a relatively stable situation , thus more stable adsorption control. If the liquid chromatography column, once below the bottom level switch (time can be set according to process requirements) to stop adsorption system requirements to protect the chromatography column.
Countercurrent wash column
Counter-current washing column is washed to remove water and broken filler particles, the specific control is: Open the purification tank discharge valve, open the chromatography column backwash valve, close the feed valve chromatography, column chromatography purification of water by the bottom of the counter-current chromatography columns at the overflow from the mouth of exclusion, by setting the cleaning time to determine the cleaning process, the procedural requirements when the cleaning time to time, the end of the counter-current washing column procedures.
Formulation Process control and confidentiality
Given the complexity of the adsorption, the program is used to control the clearance of the control step, so that the management of the process recipe is still important, so even if the operation more flexible, but also to control the process more in line with the requirements of all process recipes are rights protection can save, modify, call.
Water elution control
The main purpose of the water elution column chromatography to remove the dregs of the attachment, open the feed valve column chromatography, pure water tank discharge valve, control valve chromatography of the material to control the flow rate of washing, when the elution process set by the amount of water, close the feed valve column chromatography, pure water tank outlet valve, discharge valve chromatography.
Regeneration Control
The purpose of regeneration is to restore the ability to use chromatography columns, including the possible processes are: acid regeneration, counter-current washing column, ethanol, anti-washing and so on.
Acid-base regeneration
With approximately 4% sulfuric acid or alkaline cleaning filler, acid or dilute alkali to open the tank discharge valve, open column chromatography to find the feed valve, flow control according to the material of the chromatography material adjustment valves, control the speed of acid regeneration, when the acid regeneration process time to time set off acid or dilute alkali tank discharge valve, open the feed valve chromatography, column chromatography of the closed valve. According to the technical requirements of some of the different processes also need to: If it is acid regeneration, then soda and then washed with pure water. If the alkali regeneration, the first with acid and, then water washing.
Macroporous resin column
