Gymnema Sylvestre extract/Gymnema Sylvestre p.e 1 Appearance: Greenish powder 2 Assay: 25% HPLC
Gymnema Sylvestre extract/Gymnema Sylvestre p.e
1 Appearance: Greenish powder 2 Assay: 25% HPLC
Large climbers, rooting at nodes, leaves elliptic, acuminate, base acute to acuminate, glabrous above sparsely or densely tomentose beneath; Flowers small, in axillary and lateral umbel like cymes, pedicels long; Calyxlobes long, ovate, obtuse, pubescent; Corolla pale yellow campanulate, valvate, corona single, with 5 fleshy scales. Scales adnate to throat of corolla tube between lobes; Anther connective produced into a membranous tip, pollinia 2, erect, carpels 2,unilocular; locules many ovuled; Follicle long, fusiform1
Chemical composition.The major bioactive constituents of Gymnema sylvestris are a group of oleanane type triterpenoid saponins known as gymnemic acids. The latter contain several acylated (tigloyl, methylbutyroyl etc.,) derivatives of deacylgymnemic acid (DAGA) which is 3-O-glucuronide of gymnemagenin (3, 16, 21, 22, 23, 28-hexahydroxy-olean-12-ene)2. The individual gymnemic acids (saponins) include gymnemic acids I-VII, gymnemosides A-F, gymnemasaponins
FUNCTION AND APPLICATION
1G. sylvestre leaves contain triterpene saponins belonging to oleanane and dammarene
classes. Oleanane saponins are gymnemic acids and gymnemasaponins, while
dammarene saponins are gymnemasides. Besides this, other plant constituents are
flavones, anthraquinones, hentriacontane, pentatriacontane, α and β chlorophylls,
phytin, resins, dquercitol, tartaric acid, formic acid, butyric acid, lupeol, βamyrin
related glycosides and stigmasterol. The plant extract also tests positive for alkaloids.
Leaves of this species yield acidic glycosides and anthroquinones and their derivatives.
Gymnemic acids have antidiabetic, antisweetener and anti-inflammatory activities. The antidiabetic array of molecules has been identified as a
group of closely related gymnemic acids after it was successfully isolated and purified
from the leaves of Gymnema sylvestre. Later, the phytoconstituents of Gymnema sylvestre
were isolated, and their chemistry and structures were studied and elucidated.
Use as herbal medicine
While it is still being studied, and the effects of the herb are not entirely known, the herb
has been shown to reduce blood sugar levels when used for an extended period of time.
Additionally, Gymnema reduces the taste of sugar when it is placed in the mouth, thus some use it to fight sugar cravings. From extract of the leaves were isolated glycosides known as Gymnemic acids, which exhibit anti-sweet activity.
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