Kojic acid, CAS: 501-30-4 5-hydroxy-2-hydroxymethyl-1,4-pyrone, used in cosmetics raw materials, agriculture, food additives
Basic information:
Kojic acidChemical name: 5-hydroxy-2-hydroxymethyl-1,4-pyroneCAS NO. : 501-30-4 EINECS NO.: 207-922-4Molecular Formula: C6H6O4 Molecular Weight: 142.11Structural Formula:
Quality standard of Kojic acid, CAS: 501-30-4
Item | Specification | Results |
Appearance | White or off white crystal | White or off white crystal |
Purity,% | 99.0min | 99.56 |
Melt point,°C | 152-156 | 153.4-154.3 |
Loss on Drying, % | 0.5max | 0.23 |
Residue on Ignition, % | 0.1max | 0.08 |
Heavy Metals, ppm | 3max | 1.00 |
Iron, ppm | 10max | 7.00 |
Arsenic, ppm | 1max | 0.5 |
Chloride, ppm | 100max | 40 |
Conclusion | Complies with standard. | |
Introduction of Kojic acid, CAS: 501-30-41). Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) is a kind
of subacid organic compound made in microbial fermentation.
2). Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) is white
or off-white crystal,
3). Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) is easily dissolved in water, alcohol and acetone; slightly dissolved in ether, ethyl acetate,
chloroform and pyridine; and undissolved in benzene.
Action Mechanism in Cosmeticsbit the activity of tyrosinase and obstruct melanin formation. It also can make
skin white and light by controling cell vigor, depressing the acitivity of tyrosinase and
prohibitting DOPA oxidation.
Application: (1) Cosmetics: Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) is used for macula-removing and whitening.In the human skin, tyrosine is oxidized and polymerized with oxygen-derived free radicals under the catalytic action of tyrosinase and then synthesized to melanin. Kojic acid can inhibit tyrosinase synthesis, so it can largely inhibit the skin melanin formation; furthermore, kojic acid is safe and nontoxic and won’t cause white spot syndrome. Therefore, it has been widely added into the lotion, face mask, liquid cream and skin cream. Whitening cosmetics containing kojic acid are able to treat effectively the freckle, senile plaque, pigmentation and acne, etc. Kojic acid in concentration of 20ug/ml is able to inhibit 70~80%of the activity of many kinds of tyrosinases (or polyphenoloxidase PPO) . recommendation usage for cosmetics: 0.2~1.0%.
(2) Raw Materials: Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) is the mateial for making maltol and cthyl maltol.
(3) Medicine: Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) has no mutagenic action to eukaryotic cells. It is able to eliminate the free radicals in the human body, strengthen the activity of the leucocyte, so it is good for human health. Now kojic acid has been used as the an important material of cephalosporin-type antibiotics. The finished products have ideal effect in easing pain, relieving inflammation and curing many diseases (like headache and toothache, etc.).
(4) Agriculture: Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) is used in producing biological pesticides. 0.5-1.0% of kojic acid can be added in microelement fertilizer (crimson liquid). This kind of crop production promoter has significant effect on increasing production of grains and vegetables, no matter it is used as low-concentration foliage fertilizer for spraying or yield-increasing agent for root applying.
(5) other fields: Kojic acid, (5-hydroxy-2-hydroxymethyl-1,4-pyrone, CAS: 501-30-4) is also used as iron analytical reagent and film spotting agent, etc.
Package and Storage:1kg/bag, aluminium foil bag25kg/cardboard drum or as customers' requirementsKeep seal and shield from light. Storage out of sunlight, sealed for two years
5-Hydroxy-2-hydroxymethyl-4-pyrone, CAS: 501-30-4, Kojic acid 99%
