Adipotide121062-08-6 (skype:ycsclee123) key words:Adipotide,121062-08-6 Basic info: CAS No.: 121062-08-6 MF: C78H111N21O19 Sequence: CKGGRAKDC-GG-D(KLAKLAK)2 Molecular formula: C111H204N36O28S2 Molar Mass: 2555.22 g/mol Peptide Sequence: H-Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-Asp-(Lys-Leu-Ala-Lys-Leu-Ala-Lys)2 CID 439302 Purity: 98%min Appearance : White to off-white crystalline powder or lumps Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0° Water Content(Karl Fischer) : ≤5.0% Acetate Content(by HPLC) : ≤15.0% Amino Acid Composition : ±10% of theoretical Purity (by HPLC) :≥98.0% Single Impurity(by HPLC) :≤1.0% Peptide Content(by %N) : ≥80% Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0% Bacterial Endotoxins : ≤5EU/mg Discriptions: a.Aditpotide is an experimental weight loss peptidomimetic with the amino acid sequence CKGGRAKDC-GG-D(KLAKLAK)2, which has been developed by researchers in the United States in an effort to fight obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide. The peptide called Adipotide has been developed by U.S. researchers in the fight against the obesity . This experimental treatment has reduced by 11% the weight of the treated monkeys by reducing fatty tissue, the BMI, and waist circumference. b.Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells thereby causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell death (apoptosis) of the blood vessels supplying the adipocytes. Due to the deprivation of nutrient supply, the subsequent starvation (which causes cellular atrophy or decrease in cell size) and the accumulation of waste products in the adipocytes; an irreversible injury occurs and this leads the mitochondria to release protease enzymes called caspases (specific factors that initiate the apoptotic process) which activate the transcription (a process whereby DNA is used to create mRNA) and translation (a process whereby mRNA is used to create the nascent primary peptide) of gene sequences which ultimately leads to the production of proteins that effect the apoptotic process. c.Adipotide and Fat Loss / Weight Loss Adipotide is an experimental treatment that prevents the blood supply to fat cells. This has helped obese monkeys to lose on average 11% of their body weight in four weeks, perhaps opening the way for therapy in humans, according to a recent research study. The study, published in the journal Science Translational Medicine , shows that body mass index and waist circumference of the rhesus monkeys were reduced.
