Metformin Hydrochloride Product Name: Metformin Hydrochloride Synonyms: Metformin HCL;3-(diaminomethylidene)-1,1-dimethylguanidine hydrochloride (1:1); 1,1-dimethylbiguanide hydrochloride CAS: 1115-70-4 MF: C4H12ClN5 MW: 165.62 EINECS: 214-230-6 Assay: 99% Appearance: White crystals or white crystalline powder Chemical Property: Soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in ether and chloroform. Odorless, bitter taste. Usage: Metformin is a biguanide oral hypoglycemic agents, also known as metformin hydrochloride, Glucophage, metformin, phenformin hypoglycemic effect than to be weak, the main role is to reduce the A cell glucagon secretion, promote the conversion of glucose to glycogen, which can not stimulate islet beta cell insulin secretion. The mechanism of hypoglycemic: 1 increase the sensitivity in the peripheral tissues to insulin, increased insulin mediated glucose utilization. 2 increase the use of non insulin dependent tissue glucose, such as brain, blood cells, renal medulla, gut, skin etc.. 3 inhibition of hepatic gluconeogenesis, reduce hepatic glucose output. 4 inhibition of intestinal wall cells and glucose uptake. 5 inhibition of cholesterol biosynthesis and storage, reduce blood triglyceride, total cholesterol levels. Packing: 25kg/drum
