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Ethyl Celllulose EC N-10
Ethyl Celllulose EC N-10

1.As adhesive of granules and tablet 2.As film-forming agent in tablet 3.As reinforcing material for sustained release tablets

Ethyl Cellulose EC N10

Ethyl Cellulose can not dissolve in water, but soluble in many organic solvents were used as tablets, granules of the adhesive, can increase the hardness of tablets to reduce friability tablets, it can be used as film-forming agent to improve the appearance of tablets, isolated taste, to avoid the failure of water-sensitive drugs to prevent the influx of metamorphic change agents, promoting the safe storage of tablets, but also can be used as reinforcing material for Sustained Release Tablets.

Technical specification

Item

Grade

K Grade

N Grade

Ethoxy(WT%)

45.5-46.8

47.5-49.5

Viscosity(mPa.s)(2% solu., 20°C)

4,5,7,10,20,50,70,100,150,200,300

Loss on drying (%)

≤3.0

 

≤0.1

Residue on ignition(%)

≤0.4

Heavy Metals(ppm)

≤2.0

Arsenic(ppm)

≤3.0

Application suggestion

Specification

Reference dosage(%)

Advantages

N7PH

N10PH

N20PH

3-20

Sustained-release coating, to provide a good diffusion membrane and can also adjust the mix of water-soluble HPMC proliferation rate.

N20PH

N50PH

N100PH

10-20

Microcapsules

N7PH

N10PH

N20PH

1-5

Floating layer tablets, used as an organic solvent to form a solid coating with good adhesive film, a masking role of Smell. Often mixed with HPMC.

N10PH

N20PH

2-6

Tablet granulation binder, used as a solvent for water-sensitive drug granulation, the production has a good dissolution properties of solid tablets. The thermoplastic extrusion granulation help

Organic solvent method of solubility and dissolution

EC can be dissolved in various organic solvents, such as ethanol, isopropyl alcohol,other alcohols, ketones, aromatic and so on. Common solvent (volume ratio)

1) Toluene :Ethanol = 4:1

2) Ethanol

3) Acetone : Isopropanol = 65:35

4) Toluene : Isopropanol = 4:1

5) Methyl Acetate : Methanol = 85:15

Alcohols and aromatics in the viscosity of the mixture, going down with alcohol content higher, when alcohol accounts for 30-35%, the lowest viscosity of the composition. Dissolution method: the EC under the stirring slowly add the container filled

Package&Storage

12.5Kg / fiber drum with PE inner liner

20 feet container can load 4.5 MT with palletized and 5MT without palletized; Packing size: H500mm x D380mm

3 years under cool, dry conditions in original packing away from heat sources.It is recomended to use the product in rotation on a first-in first-out basis.

Ethyl Celllulose EC N-10

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