Shaanxi Huazhen Biotech Co.,Ltd is one of the professional China harmine manufacturers and suppliers,Website:http://www.zhenbio.com, welcome to buy pure natural, high-quality and hot sale banisterine, telepathine, telepathine alkaloid, harmine 98%, 442-51-3 from our factory. Harmine CAS No.: 442-51-3 Molecular formula：C13H12N2O Molecular weight: 212.25M.P.：262-264 °C (lit.)Appearance：light yellow crystalline powderContent：98% HPLCDescription：Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression. Harmine inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.Usage:As a MAO inhibitor, harmine inhibits the breakdown of monoamines by enzymes called monoamine oxidases. Monoamines include neurotransmitters (serotonin, dopamine), hormones (melatonin) and drugs, including many hallucinogens (psilocybin, dimethyltryptamine (DMT), mescaline). By slowing the breakdown of neurotransmitters, MAOIs can help to replenish the body's supply of these chemicals, and many MAOIs are used as antidepressants. Harmine has not been the subject of much clinical research in the treatment of depression, which could be due in part to its restricted legal status in many countries, as well as the existence of synthetic MAOIs with fewer side effects.P. harmala and B. caapi are both traditionally used for their psychoactive effects. B. caapi has a tradition of use in conjunction with plants containing the drug DMT. Traditionally, B. caapi is consumed as a drink, with or without the DMT-bearing plants (see Ayahuasca). Ordinarily, DMT is not active when taken orally, but users report very different effects when DMT is present in such beverages. Harmine and substances containing it have been used in conjunction with many other drugs by modern experimenters. Many hallucinogens appear to exhibit increased potency when used in this way.Harmine is also a useful fluorescent pH indicator. As the pH of its local environment increases, the fluorescence emission of harmine decreases.Root from harmal, Syrian rue (Peganum harmala), Banisteriopsis caapi.
