... as neohesperidin dihydrochalcone during the 1960s as part of a United States Department of Agriculture research program to find methods ... strong base, and then catalytically hydrogenated, it becomes a dihydrochalcone, a compound roughly 300-1800 times sweeter than sugar ... antivirusApplication1. Applied in edible, medicine and commodity trade, as a new-style sweetening agent, 2. Applied in milky goods, ...