... a syndrome that may include leg swelling, varicose veins, leg pain, itching, and skin ulcers. Although traditionally recommended for a ... Its seed, bark, flower, and leaves are used to make medicine. Horse chestnut contains significant amounts of a poison called esculin ... tissue swelling from bone fracture and sprains, cough, arthritis, and joint pain. 6. Horse chestnut branch bark is used for malaria ...