... , Endurobol or GSK-516) acts as a PPAR-β modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake ... in skeletal muscle tissue, and GW-501516 has been demonstrated to reverse metabolic abnormalities in obese ... effects and satiety issues associated with low blood sugar. GW-501516 also increases muscle mass, which improved glucose tolerance ...